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RO4987655
Artikelnummer: TGM-T5412-100mg
Description: RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). Target: MEK. Smiles: OCCONC(=O)c1cc(CN2OCCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F. References: Lee L, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in...
| Schlagworte: | RG7167, CH4987655 |
| Anwendung: | MEK inhibitor |
| CAS | 874101-00-5 |
| MW: | 565.28 D |
ab 72,00 €
RO4987655
Artikelnummer: Cay19488-5
RO4987655 is a MEK inhibitor (IC50 = 5 nM). It is selective for MEK over 400 kinases at 10 µM. It inhibits proliferation of COLO 205, HT-29, QG56, MIA PaCa-2, and C32 cells with IC50 values of 0.86, 1.7, 9.5, 3.3, and 8.4 nM, respectively. RO4987655 reduces tumor growth in a variety of mouse xenograft models and...
| Schlagworte: | CH4987655,... |
| CAS | 874101-00-5 |
| MW: | 565.3 D |
ab 80,00 €
CH-4987655
Artikelnummer: SYN-1188-M001
Soluble in DMSO. CH4987655 (RO4987655) is an orally active and highly selective small-molecule MEK inhibitor with an in vitro IC(50) of 5.2nM. Target: MEK , Kinase Group: PTK , Substrate: Tyrosine
| Schlagworte: | RO4987655 |
| Anwendung: | MEK inhibitor |
| CAS | 874101-00-5 |
| MW: | 565,3 D |
ab 250,00 €
