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Fevipiprant
Artikelnummer: TGM-T3965-100mg
Description: Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. Target: GPR, Prostaglandin Receptor. Smiles: Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O. References: Sykes DA, et al. Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for...
| Schlagworte: | QAW039, NVP-QAW039 |
| Anwendung: | Targets prostaglandin D2 receptor (PTGDR) |
| CAS | 872365-14-5 |
| MW: | 426.41 D |
ab 30,00 €
Fevipiprant
Artikelnummer: Cay20263-1
Fevipiprant is a DP2/CRTH2 antagonist (Ki = 1.05 nM). It reduces shape change of eosinophils induced by prostaglandin D2 (PGD2, Cay-12010) with IC50 values of 0.4 and 0.44 nM for isolated human eosinophils and human whole blood, respectively. Fevipiprant inhibits PGD2-induced release of IL-5 and IL-13 in isolated...
| Schlagworte: | NVP-QAW039, QAW039, 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-1 H -pyrrolo[2,3b]pyridine-3-acetic... |
| Anwendung: | Prostaglandin D2 receptor antagonist |
| CAS | 872365-14-5 |
| MW: | 426.4 D |
ab 78,00 €
