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Trametinib
Artikelnummer: TGM-T2125-100mg
Description: Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. Target: Apoptosis, MEK, Autophagy. Smiles:...
| Schlagworte: | JTP-74057, GSK1120212 |
| CAS | 871700-17-3 |
| MW: | 615.39 D |
ab 31,00 €
GSK1120212
Artikelnummer: LKT-G7440.5
GSK1120212 inhibits MEK1/2 and is currently in clinical trials as a potential treatment for melanoma. GSK1120212 exhibits anticancer chemotherapeutic activity, upregulating p27 expression and inhibiting growth in colorectal cancer cells and suppressing tumor growth in colorectal cancer xenografts.
| Schlagworte: | Trametinib, JTP-74057 |
| Anwendung: | MEK1/2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615.39 D |
ab 109,00 €
Trametinib
Artikelnummer: Cay16292-25
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM)...
| Schlagworte: | GSK1120212, JTP-74057,... |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615.4 D |
ab 94,00 €
GSK-1120212
Artikelnummer: SYN-1170-M010
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK1120212 (JTP-74057, trametinib) is a highly specific and potent MEK1 and MEK2 inhibitor with IC(50) values of 0.92nM and 1.8nM respectively. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
| Schlagworte: | JTP-74057, GSK212, Trametinib |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 871700-17-3 |
| MW: | 615,4 D |
ab 123,00 €
