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H-1152 dihydrochloride
Artikelnummer: TGM-T35328-100mg
Description: H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 µM, 5.68 µM, 0.360 µM, 0.745 µM and 0.180 µM, respectively. Target:...
| Schlagworte: | H-1152 dihydrochloride, H-1152 2HCl |
| Anwendung: | Cell-permeable ROCK inhibitor |
| CAS | 871543-07-6 |
| MW: | 392.34 D |
ab 58,00 €
H1152
Artikelnummer: SYN-1221-M001
Solid. Soluble in DMSO. H-1152 is a potent, specific, ATP-competitive and cell permeable ROCK inhibitor, with an IC50 of 12nM for ROCKII. H-1152 poorly inhibits PKA, PKC and myosin light chain kinase. Rho kinase (ROCK) activated by GTP-linked Rho phosphorylates targets that are involved in cytoskeletal remodelling,...
| Schlagworte: | (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride, H1152 |
| Anwendung: | Cell-permeable ROCK inhibitor |
| CAS | 871543-07-6 |
| MW: | 392,3 D |
ab 123,00 €
