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A 839977
Artikelnummer: TGM-T14076-1mg
Description: A-839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic properties, inhibiting BzATP-induced calcium efflux from the P2X7 receptor, and is used in the study of renal fibrosis. Target: P2X Receptor, Calcium Channel. Smiles: Clc1cccc(c1Cl)-n1nnnc1NCc1ccccc1Oc1ccccn1....
| Schlagworte: | A-839977, A839977 |
| Anwendung: | P2X7 receptor antagonist |
| CAS | 870061-27-1 |
| MW: | 413.26 D |
ab 38,00 €
A-839977
Artikelnummer: Cay30934-1
A-389977 is an antagonist of the purinergic P2X7 receptor. It inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human, rat, and mouse receptors (IC50s = 20, 42, and 150 nM, respectively). A-839977 inhibits BzATP-induced YO-PRO dye uptake, a marker of membrane pore formation, and IL-1beta...
| Schlagworte: | 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine |
| Anwendung: | P2X7 receptor antagonist |
| CAS | 870061-27-1 |
| MW: | 413.3 D |
ab 44,00 €
