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AZD 8330
Artikelnummer: Cay11588-1
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.Formal Name:...
| Schlagworte: | ARRY-424704, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide |
| Anwendung: | MEK inhibitor |
| CAS | 869357-68-6 |
| MW: | 461.2 D |
ab 84,00 €
AZD-8330
Artikelnummer: SYN-1195-M001
Soluble in DMSO or ethanol. AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with an IC(50) of 7nM. Target: MEK1 - MEK2 , Kinase Group: STE , Substrate: Serine-Threonine
| Schlagworte: | AZD8330 |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 869357-68-6 |
| MW: | 461,2 D |
ab 132,00 €
AZD8330
Artikelnummer: LKT-A9715.1
AZD8330 is an inhibitor of MEK1/2 that exhibits anticancer chemotherapeutic activity. AZD8330 is currently in clinical trials for the treatment of advanced stage cancers.
| Schlagworte: | ARRY-704, ARRY-424704 |
| Anwendung: | MEK1/2 inhibitor |
| CAS | 869357-68-6 |
| MW: | 461.23 D |
ab 205,00 €
