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Setipiprant
Artikelnummer: TGM-T3520-100mg
Description: Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing...
| Schlagworte: | ACT-129968, KYTH-105 |
| Anwendung: | Targets prostaglandin D2 receptor (PTGDR) |
| CAS | 866460-33-5 |
| MW: | 402.42 D |
ab 31,00 €
Setipiprant
Artikelnummer: Cay28291-5
Setipiprant is an orally bioavailable antagonist of the prostaglandin D2 (PGD2, Cay-12010) receptor CRTH2/DP2 (IC50 = 6 nM for the human receptor). It is selective for CRTH2/DP2 over DP1 in a radioligand binding assay (IC50 = 1,290 nM) and the prostaglandin E2 (PGE2, Cay-14010) receptor subtypes EP2 and EP4 in a...
| Schlagworte: | ACT-129968, 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-5H-pyrido[4,3-b]indole-5-acetic acid |
| Anwendung: | CRTH2/CD294 antagonist |
| CAS | 866460-33-5 |
| MW: | 402.4 D |
ab 67,00 €
