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5'-Fluoroindirubinoxime
5'-Fluoroindirubinoxime

Artikelnummer: TGM-T8317-100mg

Description: 5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM). Target: FLT. Smiles: O\N=C1\C(\Nc2ccccc\12)=C1/C(=O)Nc2ccc(F)cc12. References: Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1,13(1):253-9.
Schlagworte: 5'-FIO
Anwendung: FLT3 kinase inhibitor
CAS 861214-33-7
MW: 295.27 D
ab 42,00 €
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PD 082106
PD 082106

Artikelnummer: Cay29719-1

PD 082106 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3, IC50 = 0.015 µM, respectively) and a derivative of indirubin (Cay-14155). It is selective for FLT3 over Met, Ron, EGFR, and the insulin receptor (IC50s = >10 µM for all) but does inhibit DRAK2 (IC50 = 0.62 µM), as well as VEGFR2 and Aurora A (IC50s =...
Schlagworte: 5'-FIO, 5'-Fluoroindirubinoxime, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one
Anwendung: FLT3 kinase inhibitor
CAS 861214-33-7
MW: 295.3 D
ab 43,00 €
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