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WP1130
Artikelnummer: Cay15227-10
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into two subgroups: ubiquitin-specific proteases (USPs) and ubiquitin-specific COOH-terminal hydrolases...
| Schlagworte: | Degrasyn, (2E)-3-(6-bromo-2-pyridinyl)-2-cyano-N-[1S-phenylbutyl]-2-propenamide |
| Anwendung: | Tyrphostin derivate, Deubiquitinase activity inhibitor |
| CAS | 856243-80-6 |
| MW: | 384.3 D |
ab 92,00 €
WP1130
Artikelnummer: AG-CR1-3551-M001
WP1130 is a second-generation tyrphostin derivative initially identified as a JAK2 signaling inhibitor through JAK2 ubiquitination that reduces STAT activation stimulated by cytokines (such as IL-6 and IL-3) through the rapid down-regulation of upstream JAK kinases. WP1130 has also been identified as a partially...
| Schlagworte: | WPI 130, Degrasyn, (2E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide |
| Anwendung: | Second-generation tyrphostin derivative, JAK2 signaling inhibitor, JAK2 ubiquitination inducer |
| CAS | 856243-80-6 |
| MW: | 384,3 D |
ab 33,00 €
