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Afatinib
Artikelnummer: TGM-T21312-5mg
Description: Afatinib (BIBW 2992) is an irreversible inhibitor of the EGFR family (EGFR-wt, EGFR-L858R, EGFR-L858R/T790M, and HER2) with IC50s of 0.5 nM, 0.4 nM, 10 nM, and 14 nM, respectively. Target: Autophagy, EGFR. Smiles: N(C=1C2=C(C=C(O[C@H]3CCOC3)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C4=CC(Cl)=C(F)C=C4. References:...
| Schlagworte: | BIBW 2992, Afatinib free base |
| CAS | 850140-72-6 |
| MW: | 485.94 D |
ab 31,00 €
Afatinib
Artikelnummer: Cay11492-5
Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces...
| Schlagworte: | BIBW 2992,... |
| Anwendung: | EGFR / HER2 kinase inhibitor |
| CAS | 850140-72-6 |
| MW: | 485.9 D |
ab 36,00 €
