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Afatinib
Artikelnummer: Cay11492-5
Afatinib is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and ErbB2 (IC50s = 0.5 and 14 nM, respectively). It increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein. Afatinib (20 mg/kg) reduces...
| Schlagworte: | BIBW 2992,... |
| Anwendung: | EGFR / HER2 kinase inhibitor |
| CAS | 850140-72-6 |
| MW: | 485.9 D |
ab 35,00 €
Afatinib, Free Base (BIBW-2992, Giotrif, Gilotrif, Tovok,...
Artikelnummer: LC-A-8644_1g
Soluble in DMSO at 200 mg/mL, soluble in ethanol at 25 mg/mL, very poorly soluble in water, maximum solubility in plain water is estimated to be about 50-100 µM, buffers, serum, or other additives may increase or decrease the aqueous solubility
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 850140-72-6 |
| MW: | 485,94 D |
ab 91,00 €
