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Bitopertin
Artikelnummer: TGM-T6788-100mg
Description: Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells. Target: GlyT. Smiles: C[C@H](Oc1ccc(cc1C(=O)N1CCN(CC1)c1ncc(cc1F)C(F)(F)F)S(C)(=O)=O)C(F)(F)F. References:...
| Schlagworte: | RO4917838, Paliflutine, RG1678 |
| Anwendung: | Targets solute carrier family 6 (neurotransmitter transporter, glycine) member 5/9 (SLC6A5_9, GLYT) |
| CAS | 845614-11-1 |
| MW: | 543.46 D |
ab 35,00 €
Bitopertin
Artikelnummer: Cay19896-10
Bitopertin is an inhibitor of glycine transporter 1 (GlyT1, IC50 = 0.03 µM). It is selective for GlyT1 over GlyT2 (IC50 = >30 µM) as well as a panel of 107 receptors, transporters, and enzymes at 10 µM. Bitopertin (0.1 µM) increases long-term potentiation in rat hippocampal CA1 slices. It reverses hyperlocomotion...
| Schlagworte: | RG-1678, RO-4917838,... |
| Anwendung: | GlyT1 inhibitor |
| CAS | 845614-11-1 |
| MW: | 543.5 D |
ab 163,00 €
