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GSK180736A
Artikelnummer: TGM-T3513-100mg
Description: GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 µM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 µM), but highly effective against ROCK1 (IC50: 100 nM). Target: ROCK, GRK, PKA. Smiles: CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1....
| Schlagworte: | GSK180736 |
| Anwendung: | ROCK1 inhibitor |
| CAS | 817194-38-0 |
| MW: | 365.36 D |
ab 37,00 €
GSK180736A
Artikelnummer: Cay26182-10
GSK180736A is an inhibitor of Rho-associated kinase 1 (ROCK1, IC50 = 14 nM) and G protein-coupled receptor kinase 2 (GRK2, IC50 = 0.77 µM). It is selective for GRK2 over GRK1, GRK5, and PKA (IC50 = >100 µM for all) and selective for ROCK1 over RSK1 and p20S6K (IC50s = 3,100 and 2,850 nM, respectively). GSK180736A...
| Schlagworte: | 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide |
| Anwendung: | ROCK1 inhibitor |
| CAS | 817194-38-0 |
| MW: | 365.4 D |
ab 128,00 €
