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GNF-2
GNF-2

Artikelnummer: Cay16253-1

GNF-2 is an allosteric inhibitor of Bcr-Abl (IC50 = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 µM. It inhibits proliferation of Ba/F3 cells (IC50 = 138 nM). GNF-2 (10 µM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus,...
Schlagworte: Bcr-Abl Inhibitor, 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide
Anwendung: Bcr-abl inhibitor
CAS 778270-11-4
MW: 374.3 D
ab 128,00 €
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GNF-2
GNF-2

Artikelnummer: LKT-G5320.1

GNF-2 is an inhibitor of Abl kinase that exhibits anticancer chemotherapeutic, anti-resorptive, and anti-osteoporotic activities. GNF-2 shows potential benefit in the treatment of Philadelphia chromosome-positive acute myelogenous leukemia (ALL). In vitro, GNF-2 inhibits differentiation of osteoclasts, activity of...
Anwendung: Bcr-abl inhibitor
CAS 778270-11-4
MW: 374.32 D
ab 156,00 €
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