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T863
Artikelnummer: TGM-T4681-100mg
Description: T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 (DGAT-3) causes weight loss, reduction in...
| Schlagworte: | DGAT-3, DGAT-1 inhibitor |
| Anwendung: | DGAT1 inhibitor |
| CAS | 701232-20-4 |
| MW: | 394.47 D |
ab 33,00 €
T-863
Artikelnummer: Cay25807-1
T-863 is a potent inhibitor of diacylglycerol acetyltransferase-1 (DGAT-1, IC50 = 15 nM). It is selective for DGAT-1 over DGAT-2 and acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1, IC50s = >10 and 12 µM, respectively). T-863 inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 4 nM). In vivo, T-863 (20...
| Schlagworte: | trans-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid |
| Anwendung: | DGAT1 inhibitor |
| CAS | 701232-20-4 |
| MW: | 394.5 D |
ab 54,00 €
