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Poloppin
Artikelnummer: TGM-T24652-10mg
Description: Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells. Target: Others. Smiles:...
| Anwendung: | Plk1-Plk1-binding phosphopeptide protein-peptide interaction inhibitor |
| CAS | 683808-78-8 |
| MW: | 438.24 D |
ab 65,00 €
Poloppin
Artikelnummer: Cay38330-1
Poloppin is an inhibitor of the protein-peptide interaction between polo-like kinase 1 (Plk1) and the Plk1-binding phosphopeptide (IC50 = 26.9 µM). It induces mitotic arrest in HeLa cells (EC50 = 29.9 µM). Poloppin inhibits cell growth in murine pancreatic organoids expressing mutant K-Ras (GI50s = 22.92-28.39...
| Schlagworte: | Polo Protein-protein Interaction Inhibitor, 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-2-propanoic acid |
| Anwendung: | Plk1-Plk1-binding phosphopeptide protein-peptide interaction inhibitor |
| CAS | 683808-78-8 |
| MW: | 438.2 D |
ab 35,00 €
