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IU1-47
Artikelnummer: TGM-T15604-100mg
Description: IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 µM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 µM). Target: DUB. Smiles: Cc1cc(C(=O)CN2CCCCC2)c(C)n1-c1ccc(Cl)cc1. References: Boselli M, et al. An inhibitor of the proteasomal deubiquitinating...
| Anwendung: | USP14 inhibitor |
| CAS | 670270-31-2 |
| MW: | 330.85 D |
ab 51,00 €
IU1-47
Artikelnummer: Cay34095-10
IU1-47 is an inhibitor of ubiquitin-specific protease 14 (USP14, IC50 = 0.6 µM). It is selective for USP14 over USP5 (IC50 = 20 µM). IU1-47 increases degradation of a ubiquitinated proteasome substrate in a cell-free assay. It reduces tau levels in wild-type mouse embryonic fibroblasts (MEFs) expressing human tau...
| Schlagworte: | 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)-ethanone |
| Anwendung: | USP14 inhibitor |
| CAS | 670270-31-2 |
| MW: | 330.9 D |
ab 109,00 €
