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BRD6989
Artikelnummer: TGM-T14778-100mg
Description: BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. Target: IL Receptor, CDK, Interleukin. Smiles:...
| Anwendung: | Cdk8/cyclin C complex inhibitor |
| CAS | 642008-81-9 |
| MW: | 264.33 D |
ab 31,00 €
BRD6989
Artikelnummer: Cay35358-10
BRD6989 is an inhibitor of the Cdk8/cyclin C complex. It selectively binds to the Cdk8/cyclin C complex (IC50 = ~200 nM) over the Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p35, Cdk7/cyclin H, and Cdk9/cyclin T complexes at 1,000 nM. BRD6989 increases the production of IL-10 in primary mouse bone marrow-derived dendritic...
| Schlagworte: | 2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile |
| Anwendung: | Cdk8/cyclin C complex inhibitor |
| CAS | 642008-81-9 |
| MW: | 264.3 D |
ab 113,00 €
