Zu "639089-54-6" wurden 4 Artikel gefunden!
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Tozasertib
Artikelnummer: SYN-1092-M001
Soluble in DMSO or ethanol. In mammals, three Aurora kinases, Aurora A, Aurora B, and Aurora C, are expressed. Aurora C expression is mainly restricted to testis, where it functions during meiosis, whereas Aurora A and B play key functions regulating mitosis. Aurora A is localized to the centrosome and spindle...
| Schlagworte: | MK-0457, VX-680 |
| Anwendung: | Aurora inhibitor |
| CAS | 639089-54-6 |
| MW: | 464,6 D |
ab 66,00 €
![Tozasertib, Free Base (N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidi](https://www.biomol.com/media/image/0a/a0/e5/T8078-10_200x200.jpg "Tozasertib, Free Base (N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidi")
Tozasertib, Free Base...
Artikelnummer: T8078.10
Tozasertib is a potent inhibitor of all aurora kinases, including the A, B and C isotypes (Ki=0.6nM, 18nM and 4.6nM, respectively). It also inhibits ABL kinase (Ki=30nM), an imatinib-resistant ABL mutant (T315I) kinase (Ki=42nM), and Flt-3 (Ki=30nM). Tozasertib binds to an inactive aurora conformation. Solubility:...
| CAS | 639089-54-6 |
| MW: | 464.59 |
107,00 €
MK-0457
Artikelnummer: Cay13600-100
The Aurora kinases (A, B, and C) are a family of serine-threonine kinases that regulate various stages of mitotic function. With significant roles in cell cycle and cell division, Aurora kinase gene amplification and overexpression are linked to tumorigenesis. MK-0457 is a potent pan-Aurora kinase inhibitor but...
| Schlagworte: | Tozasertib, VX-680,... |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 639089-54-6 |
| MW: | 464.6 D |
ab 115,00 €
Tozasertib
Artikelnummer: LKT-T5996.25
Tozasertib (VX680) is an Aurora kinase inhibitor found to suppress tumor growth.
| Schlagworte: | VX680, MK0457, VX-680, MK-0457 |
| Anwendung: | Aurora kinase inhibitor |
| CAS | 639089-54-6 |
| MW: | 464,59 D |
ab 79,00 €
