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A 77-01
Artikelnummer: TGM-T2098-100mg
Description: A 77-01 is a potent inhibitor of the TGF-(beta) type I receptor superfamily activin-like kinase ALK5, with an IC50 of 25 nM. Target: ALK, TGF-beta/Smad. Smiles: Cc1cccc(n1)-c1n[nH]cc1-c1ccnc2ccccc12. References: Tojo M, et al. Y Sci. 2005 Nov,96(11):791-800.
| Schlagworte: | A77-01 |
| CAS | 607737-87-1 |
| MW: | 286.33 D |
ab 42,00 €
A-77-01
Artikelnummer: Cay18396-1
A-77-01 is a potent inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-beta on lung epithelial Mv1Lu cells. It completely blocks phosphorylation of SMAD2 by TGF-beta...
| Schlagworte: | 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinoline |
| Anwendung: | ALK5 inhibitor |
| CAS | 607737-87-1 |
| MW: | 286.3 D |
ab 55,00 €
