Zu "58880-19-6" wurden 4 Artikel gefunden!
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Trichostatin A
Artikelnummer: Cay89730-1
Trichostatin A is a potent, reversible inhibitor of class I, II, and IV histone deacetylases (HDACs). In human Jurkat T cells, trichostatin A arrests cell cycle progression in G1 and inhibits the activity of HDAC1 with an IC50 value of 70 nM. Trichostatin A selectively inhibits the removal of acetyl groups from the...
| Schlagworte: | TSA, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
| Anwendung: | HDAC inhibitor |
| CAS | 58880-19-6 |
| MW: | 302.4 D |
ab 76,00 €
Trichostatin A
Artikelnummer: TGM-T6270-10mg
Description: Trichostatin A (TSA), a natural derivative of diene isohydroxamic acids, is a specific and reversible histone deacetylase inhibitor (IC50=1.8 nM) that induces hyperacetylation of core histones to regulate chromatin structure. Target: HDAC. Smiles: C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C....
| Schlagworte: | TSA |
| Anwendung: | Apoptosis Inducer |
| CAS | 58880-19-6 |
| MW: | 302.37 D |
ab 84,00 €
Trichostatin A (synthetic)
Artikelnummer: AG-CN2-0523-M001
Off-white solid. Soluble in DMSO, ethanol, methanol, dimethyl formamide, acetonitrile or chloroform. Insoluble in water or hexane. Chemical. CAS: 58880-19-6. Formula: C17H22N2O3. MW: 302.4. Synthetic. Originally isolated from Streptomyces hygroscopicus.. Antibiotic, antifungal and antiprotozoal agent. Potent and...
| Schlagworte: | TSA, A300, R-(E,E)-7-(4-(Dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide |
| CAS | 58880-19-6 |
| MW: | 302,4 D |
ab 99,00 €
Trichostatin A
Artikelnummer: LKT-T6933.1
A histone deacetylase inhibitor. It induces apoptotic cell death in cancer cells. Research results suggest that TSA induces pro-apoptotic genes like ID1, ID2, ID3, down regulates anti-apoptotic genes like Hsp 27 and Bcl-xL and induces activities of calcium/calmodulin dependent kinase II and protein kinase C, which...
| Schlagworte: | TSA |
| Anwendung: | HDAC inhibitor |
| CAS | 58880-19-6 |
| MW: | 302,37 D |
ab 277,00 €
