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SMI-16a
Artikelnummer: TGM-T3989-100mg
Description: SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against a panel of 57 other kinases (=18% inhibition at 5 µM). Target: Pim. Smiles:...
| Schlagworte: | PIM1/2 Kinase Inhibitor VI |
| Anwendung: | Pim-1 kinase inhibitor |
| CAS | 587852-28-6 |
| MW: | 263.31 D |
ab 31,00 €
![5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione](https://www.biomol.com/media/image/db/be/dd/CDX-P0110-M005_200x200.png "5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione")
5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione
Artikelnummer: CDX-P0110-M005
Yellow powder. Soluble in DMSO. Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µ,M), while exhibiting little or no activity against a panel of 57 other kinases...
| Schlagworte: | (Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione, SMI-16a |
| Anwendung: | Cell-permeable Pim-1/2 inhibitor |
| CAS | 587852-28-6 |
| MW: | 263,3 D |
ab 114,00 €
SMI-16a
Artikelnummer: Cay29456-10
SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 µM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest...
| Schlagworte: | 5-[(4-propoxyphenyl)methylene]-2,4-thiazolidinedione |
| Anwendung: | Pim-1 kinase inhibitor |
| CAS | 587852-28-6 |
| MW: | 263.3 D |
ab 128,00 €
