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Rolapitant
Artikelnummer: TGM-T3716-100mg
Description: Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity...
| Schlagworte: | SCH619734 |
| Anwendung: | Targets tachykinin receptor 1 (TACR1) |
| CAS | 552292-08-7 |
| MW: | 500.48 D |
ab 45,00 €
Rolapitant
Artikelnummer: Cay23906-10
Rolapitant is a potent neurokinin-1 (NK1) receptor antagonist (Ki = 0.66 nM for the human receptor). It is greater than 1,000-fold selective for NK1 over NK2 and NK3 and lacks activity in a panel of 100 receptors, transporters, enzymes, and ion channels. Rolapitant inhibits GR-73632-induced calcium efflux in CHO...
| Schlagworte: | (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one |
| Anwendung: | Antiemetic, Neurokinin NK1 antagonist |
| CAS | 552292-08-7 |
| MW: | 500.5 D |
ab 44,00 €
