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Tubacin
Artikelnummer: Cay13691-1
Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM). In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 µM). Tubacin induces alpha-tubulin hyperacetylation at 2.5 µM in primary cortical...
| Schlagworte: | N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy... |
| Anwendung: | Tubulin acetylation inducer, HDAC6 inhibitor |
| CAS | 537049-40-4 |
| MW: | 721.9 D |
ab 142,00 €
Tubacin
Artikelnummer: LKT-T8000.1
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM. The IC50 for other HDACs is 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Tubacin inhibits alpha-tubulin deacetylation in mammalian cells....
| Schlagworte: | N1-(4-((2R,4R,6S)-4-(((4,5-diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxy... |
| Anwendung: | HDAC6 inhibitor |
| CAS | 537049-40-4 |
| MW: | 721.86 D |
ab 485,00 €
