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Artikelnummer: TGM-T16011-1mg

Description: Manumycin A is an antibiotic with anticancer activity and is a mammalian thioredoxin reductase-1 (TrxR-1) inhibitor.Manumycin A inhibits the production of IL-1beta, IL-6, and IL-8 in TNF alpha-stimulated THP-1 cells and peripheral blood mononuclear cells in a dose-dependent manner, inducing apoptosis....

Anwendung:	Rasfarnesyltransferase inhibitor
CAS	52665-74-4
MW:	550.64 D

ab 272,00 €

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Manumycin A

Artikelnummer: BVT-0091-M001

Antibiotic, Potent, selective and competitive cell-permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM), Does not affect geranylgeranyltransferase (IC50 = 180 µM), Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras, Neutral sphingomyelinase inhibitor, Blocks...

Anwendung:	Rasfarnesyltransferase inhibitor
CAS	52665-74-4
MW:	550,6 D

ab 100,00 €

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Manumycin A

Artikelnummer: Cay10010497-1

Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant...

Schlagworte:	NSC 622141, UCF 1C,...
Anwendung:	FTase inhibitor
CAS	52665-74-4
MW:	550.7 D

ab 149,00 €

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Manumycin A

Artikelnummer: AG-CN2-2000-M010

Antibiotic. Apoptosis and endoplasmic reticulum stress-mediated cell death inducer. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50 = 30 nM). Does not affect geranylgeranyltransferase (IC50 = 180 µM). Inhibition is competitive with respect to farnesyl pyrophosphate and...