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Genz-123346 free base
Artikelnummer: TGM-T4049-100mg
Description: Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. Target: Glucokinase. Smiles: CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1. References: Zhao H, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal...
| Anwendung: | Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor |
| CAS | 491833-30-8 |
| MW: | 418.57 D |
ab 43,00 €
Genz-123346
Artikelnummer: Cay28500-100
Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM). It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day. Genz-123346 (125...
| Schlagworte: | N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-nonanamide |
| Anwendung: | Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor |
| CAS | 491833-30-8 |
| MW: | 418.6 D |
ab 175,00 €
