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Navarixin
Artikelnummer: TGM-T7130-100mg
Description: Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia. Target:...
| Schlagworte: | MK-7123, SCH 527123 |
| Anwendung: | Allosteric CXCR1 antagonist |
| CAS | 473727-83-2 |
| MW: | 397.42 D |
ab 34,00 €
SCH 527123
Artikelnummer: Cay27800-1
SCH 527123 is an allosteric antagonist of C-X-C chemokine receptor type 1 (CXCR1, IC50 = 43 nM in Ba/F3 cells) and CXCR2 (IC50 = 0.97 nM in HTS cells). It inhibits calcium flux induced by CXCL8 in Ba/F3 cells expressing human recombinant CXCR1 or CXCR2. SCH 527123 (3 nM) inhibits CXCL8-induced chemotaxis of Ba/F3...
| Schlagworte: | MK-7123, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-benzamide |
| Anwendung: | Allosteric CXCR1 antagonist |
| CAS | 473727-83-2 |
| MW: | 397.4 D |
ab 35,00 €
