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JNJ-7706621
Artikelnummer: TGM-T6126-100mg
Description: JNJ-7706621 is a potent aurora kinase inhibitor that also inhibits CDK1 and CDK2. Target: Aurora Kinase, CDK, Apoptosis. Smiles: Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F. References: Emanuel S, et al. Cancer Res, 2005, 65(19), 9038-9046.
| Schlagworte: | JNJ 7706621 |
| Anwendung: | Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Aurora A/B inhibitor |
| CAS | 443797-96-4 |
| MW: | 394.36 D |
ab 43,00 €
JNJ-7706621
Artikelnummer: Cay18494-1
JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC50s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity...
| Schlagworte: | Aurora A Inhibitor I, Aurora Kinase/CDK Inhibitor,... |
| Anwendung: | Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Aurora A/B inhibitor |
| CAS | 443797-96-4 |
| MW: | 394.4 D |
ab 60,00 €
JNJ-7706621
Artikelnummer: SYN-1048-M001
Soluble in DMSO or ethanol. JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and aurora kinases. It demonstrates highest potency on CDK1/2 with IC(50) values of 9nM and 4nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6. Target: Aurora - CDK , Kinase Group: Other ,...
| Schlagworte: | JNJ7706621 |
| Anwendung: | Aurora / CDK1 / CDK2 inhibitor |
| CAS | 443797-96-4 |
| MW: | 394,4 D |
ab 165,00 €
