Zu "441798-33-0" wurden 2 Artikel gefunden!
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Macitentan
Artikelnummer: Cay23304-100
Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...
| Schlagworte: | ACT-064992, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide |
| Anwendung: | Dual EDNRA / EDNRB antagonist |
| CAS | 441798-33-0 |
| MW: | 588.3 D |
ab 54,00 €
Macitentan
Artikelnummer: LKT-M0009.1
Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as...
| Schlagworte: | ACT-064992, Actelion-1 |
| Anwendung: | Endothelin receptor type A antagonist, Endothelin receptor type B antagonist |
| CAS | 441798-33-0 |
| MW: | 588.27 D |
ab 73,00 €
