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C188-9
Artikelnummer: TGM-T4650-100mg
Description: C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 µM. Target: STAT, Apoptosis. Smiles: COc1ccc(cc1)S(=O)(=O)Nc1cc(c(O)c2ccccc12)-c1c(O)ccc2ccccc12. References: edell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by...
| Schlagworte: | TTI-101 |
| Anwendung: | STAT3 inhibitor |
| CAS | 432001-19-9 |
| MW: | 471.52 D |
ab 38,00 €
C188-9
Artikelnummer: Cay30928-5
C188-9 is a STAT3 inhibitor. It binds to the phosphotyrosyl peptide binding site in the STAT3 Src homology 2 (SH2) domain (Ki = 136 nM) and inhibits G-CSF-induced activation of STAT3 in patient-derived acute myeloid leukemia (AML) cells (IC50s = 8-18 µM). C188-9 induces apoptosis in patient-derived AML cells (EC50s...
| Schlagworte: | N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-benzenesulfonamide |
| Anwendung: | STAT3 inhibitor |
| CAS | 432001-19-9 |
| MW: | 471.5 D |
ab 117,00 €
