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Sotrastaurin
Artikelnummer: TGM-T6278-5mg
Description: Sotrastaurin (AEB071) is a potent pan-PKC inhibitor with Kis of 0.95 nM for PKCalpha, 0.64 nM for PKCbetaI, 2.1 nM for PKCdelta, 3.2 nM for PKCepsilon, 1.8 nM for PKCeta, and 0.22 nM for PKCtheta. Target: PKC. Smiles: CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1. References: Evenou JP, et...
| Schlagworte: | AEB071 |
| Anwendung: | Targets novel protein kinase C delta type [EC:2.7.11.13] (PRKCD) |
| CAS | 425637-18-9 |
| MW: | 438.48 D |
ab 45,00 €
Sotrastaurin
Artikelnummer: Cay16726-1
Sotrastaurin is a protein kinase C (PKC) inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-kappaB signaling. In cell-free assays, sotrastaurin was reported to inhibit PKCalpha, betaI, delta, epsilon, eta, and theta with Ki values of 0.95, 0.64,...
| Schlagworte: | AEB071, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-1H-pyrrole-2,5-dione |
| Anwendung: | PKC inhibitor, immunosuppressor |
| CAS | 425637-18-9 |
| MW: | 438.5 D |
ab 67,00 €
