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PHA-680632
Artikelnummer: TGM-T6338-100mg
Description: PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. Target: FGFR, Aurora Kinase, PLK. Smiles:...
| Schlagworte: | PHA 680632, PHA680632 |
| Anwendung: | Aurora A/B/C kinase inhibitor |
| CAS | 398493-79-3 |
| MW: | 501.62 D |
ab 39,00 €
PHA-680632
Artikelnummer: Cay28381-10
PHA-680632 is an inhibitor of Aurora A, B, and C kinases (IC50s = 27, 135, and 120 nM, respectively). It has greater than 15-fold selectivity for Aurora A kinase in a panel of 31 kinases. PHA-680632 inhibits phosphorylation of serine 10 on histone H3 in U2OS cells (IC50 = 0.39 µM). It inhibits proliferation of U2OS,...
| Schlagworte: | N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide |
| Anwendung: | Aurora A/B/C kinase inhibitor |
| CAS | 398493-79-3 |
| MW: | 501.6 D |
ab 65,00 €
