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YM-201636
Artikelnummer: TGM-T6110-100mg
Description: YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110alpha and insensitive to Fabl, which is yeast orthologue. Target: Autophagy, PI3K, Influenza Virus. Smiles: Cl.Nc1ccc(cn1)C(=O)Nc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1. References: Jefferies HB, et al. EMBO Rep, 2008, 9(2),...
| Anwendung: | PIKfyve inhibitor |
| CAS | 371942-69-7 |
| MW: | 467.48 D |
ab 42,00 €
YM-201636
Artikelnummer: Cay13576-1
PIKfyve is a phosphoinositide kinase (PIK) that contains a FYVE-type zinc finger domain, which binds phosphatidylinositol 3-phosphate (PI3P). PIKfyve phosphorylates PI3P to produce PI-(3,5)-P2, which is involved in cellular processes including membrane trafficking and cytoskeletal reorganization. YM-201636 is a...
| Schlagworte: | 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide |
| Anwendung: | PIKfyve inhibitor |
| CAS | 371942-69-7 |
| MW: | 467.5 D |
ab 69,00 €
YM201636
Artikelnummer: LKT-Y4802.1
YM201636 is an inhibitor of PIKfyve, decreasing the synthesis of phosphatidylinositol 3,5-disphosphate. YM210636 decreases muscular contraction-stimulated glucose uptake in vitro and induces autophagy-dependent neuronal death in other cellular models. Additionally, YM210636 inhibits endomembrane transport and...
| Anwendung: | PIKfyve inhibitor |
| CAS | 371942-69-7 |
| MW: | 469.5 D |
ab 202,00 €
YM201636 hydrochloride
Artikelnummer: SYN-1094-M001
Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. YM-201636 is a cell-permeable and selective inhibitor of PIKfyve (IC(50) of 33nM). It disrupts retroviral budding from cells, apparently by interfering with the endosomal sorting complex required for transport (ESCRT) machinery. In adipocytes, YM-201636 also...
| Schlagworte: | YM-201636 |
| Anwendung: | PIKfyve inhibitor |
| CAS | 371942-69-7 |
| MW: | 503,9 D |
ab 154,00 €
