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AY 9944
Artikelnummer: TGM-T14362-1mg
Description: AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Delta7-Delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]....
| Anwendung: | DHCR7 inhibitor |
| CAS | 366-93-8 |
| MW: | 464.3 D |
ab 37,00 €
AY 9944
Artikelnummer: Cay14611-1
AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Delta7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Cay-14612) to cholesterol. Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the...
| Schlagworte: | trans-N1,N4-bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine, dihydrochloride |
| Anwendung: | DHCR7 inhibitor |
| CAS | 366-93-8 |
| MW: | 464.3 D |
ab 47,00 €
