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Pemetrexed (sodium salt hydrate)
Artikelnummer: Cay14269-5
Pemetrexed is an antifolate with anticancer activity. It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased...
| Schlagworte: | N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt,... |
| Anwendung: | Antifolate |
| CAS | 357166-29-1 |
| MW: | 597.5 D |
ab 82,00 €
![Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin](https://www.biomol.com/media/image/c0/04/6c/P3148-07-250_200x200.jpg "Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin")
Pemetrexed, Disodium Salt, Heptahydrate...
Artikelnummer: P3148-07.250
Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Solubility: Very poorly soluble in DMSO and ethanol, soluble in water at 100mg/ml.. Buffers, serum, or other additives may increase or decrease the...
| CAS | 357166-29-1 |
| MW: | 597.48 |
245,00 €
