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Poloxin
Artikelnummer: TGM-T16560-100mg
Description: Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor targeting the polo-box domain (IC50: appr 4.8 µM). Target: PLK. Smiles: CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O. References: Yuan J, et al. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor...
| Anwendung: | Plk1 polo-box domain inhibitor |
| CAS | 321688-88-4 |
| MW: | 297.35 D |
ab 33,00 €
Poloxin
Artikelnummer: Cay36018-10
Poloxin is an inhibitor of the polo-like kinase 1 (Plk1) polo-box domain (PBD, apparent IC50 = 4.8 µM). It is selective for the Plk1 PBD over Plk2 and Plk3 PBDs (IC50s = 18.7 and 53.9 µM, respectively). Poloxin (5, 10, and 25 µM) induces cell cycle arrest at the G2/M phase, apoptosis, and mislocalization of Plk1 in...
| Schlagworte: | 1-[O-(2-methylbenzoyl)oxime]2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione |
| Anwendung: | Plk1 polo-box domain inhibitor |
| CAS | 321688-88-4 |
| MW: | 297.4 D |
ab 62,00 €
