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GRA Ex-25
Artikelnummer: TGM-T3422-100mg
Description: GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor. Target: Glucagon Receptor. Smiles: CC(C)(C)[C@H]1CC[C@@H](CC1)N(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1. References: Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3,14(9):2047-50.
| Schlagworte: | GRA-Ex-25 |
| Anwendung: | Glucagon receptor (GCGR) antagonist |
| CAS | 307983-31-9 |
| MW: | 563.61 D |
ab 57,00 €
GRA Ex-25
Artikelnummer: Cay29727-1
GRA Ex-25 is a glucagon receptor (GCGR) antagonist (IC50s = 55 and 56 nM for the human and rat receptors, respectively). It inhibits adenylate cyclase activity induced by glucagon (Cay-24204) with a Ki value of 254 nM. GRA Ex-25 (3 mg/kg, i.v.) reduces glucagon-induced increases in blood glucose levels in...
| Schlagworte: | N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-beta-alanine |
| Anwendung: | Glucagon receptor (GCGR) antagonist |
| CAS | 307983-31-9 |
| MW: | 563.6 D |
ab 44,00 €
