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SL327
Artikelnummer: TGM-T2708-100mg
Description: SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 µM/0.22 µM, able to transport through the blood-brain barrier. Target: DNA/RNA Synthesis, MEK. Smiles: NC(Sc1ccc(N)cc1)=C(C#N)c1ccccc1C(F)(F)F. References: Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.
| Schlagworte: | SL 327, SL-327 |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 305350-87-2 |
| MW: | 335.35 D |
ab 48,00 €
SL 327
Artikelnummer: Cay15598-5
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 µM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much...
| Schlagworte: | alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-benzeneacetonitrile |
| Anwendung: | MEK1 / MEK2 inhibitor |
| CAS | 305350-87-2 |
| MW: | 335.4 D |
ab 77,00 €
