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Senicapoc
Artikelnummer: TGM-T3528-100mg
Description: Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in...
| Schlagworte: | ICA-17043 |
| Anwendung: | Targets phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta |
| CAS | 289656-45-7 |
| MW: | 323.34 D |
ab 33,00 €
Senicapoc
Artikelnummer: Cay29679-50
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (Cay-11016, IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per...
| Schlagworte: | ICA-17043, 4-fluoro-alpha-(4-fluorophenyl)-alpha-phenyl-benzeneacetamide |
| Anwendung: | KCNN4 (IKCa1/KCa3.1) inhibitor |
| CAS | 289656-45-7 |
| MW: | 323.3 D |
ab 44,00 €
