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Sorafenib
Artikelnummer: Cay10009644-10
Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively). It is selective for these kinases over 12 other kinases, including ERK1,...
| Schlagworte: | BAY 43-9006, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Anwendung: | Kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.8 D |
ab 44,00 €
Sorafenib
Artikelnummer: TGM-T0093L-100mg
Description: Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRbeta, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death. Target: VEGFR,...
| Schlagworte: | Bay 43-9006 |
| CAS | 284461-73-0 |
| MW: | 464.82 D |
ab 31,00 €
Sorafenib
Artikelnummer: LKT-S5868.25
c-Raf, Ret, VEGFR2 inhibitor, potential STAT3/5 inhibitor, potential HMT inhibitor.
| Schlagworte: | 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide |
| Anwendung: | BRAF / FLT3 / PDGFRB / VEGFR2 / VEGFR3 / c-KIT inhibitor |
| CAS | 284461-73-0 |
| MW: | 464.82 D |
ab 109,00 €
Sorafenib, Free Base (BAY-43-9006)
Artikelnummer: S5343-01.1
Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-b and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor...
| CAS | 284461-73-0 |
| MW: | 464.82 |
ab 288,00 €
BAY 43-9006
Artikelnummer: AG-CR1-0025-M005
Antitumor compound, Broad-spectrum kinase inhibitor, Raf kinase inhibitor, Apoptosis inducer, Cytostatic, Angiogenesis inhibitor, Review.
| Schlagworte: | Sorafenib, N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide |
| Anwendung: | Raf kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 464,8 D |
ab 17,00 €
Sorafenib Tosylate, kinase inhibitor
Artikelnummer: BPS-27014
Sorafenib Tosylate, also known as Bay 43-9006, is a novel bi-aryl urea compound that inhibits cell proliferation by targeting receptor tyrosine kinases, including VEGFR-2 and PDGFR-ß and their associated signaling cascades of the ERK pathway and angiogenesis. It was originally developed as a Raf kinase inhibitor. It...
| Schlagworte: | Sorafenib Tosylate, Bay 43-9006, |
| Anwendung: | Tyrosine kinase inhibitor |
| CAS | 284461-73-0 |
| MW: | 637.03 kD |
270,00 €