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Rucaparib
Artikelnummer: TGM-T4463-100mg
Description: Rucaparib (PF-01367338) is a PARP protein inhibitor (PARP-1 Ki=1.4 nM) and hexose hexose-6-phosphate dehydrogenase (H6PD) inhibitor with oral activity. Rucaparib exhibits antitumor activity, with activity against desmoplasia-resistant prostate cancer (CRPC). Target: PARP. Smiles:...
| Schlagworte: | AG014699, AG-14447, PF-01367338 |
| Anwendung: | Targets poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] (PARP1) |
| CAS | 283173-50-2 |
| MW: | 323.36 D |
ab 41,00 €
Rucaparib
Artikelnummer: Cay15643-1
Poly(ADP-ribose) polymerases (PARPs) are activated by DNA single- and double-strand breaks and promote repair of DNA damage through the relaxation of chromatin and recruitment of other repair proteins. Inhibition of PARP activity has been linked to synthetic lethality in cells with mutations in BRCA1 or BRCA2 and is...
| Schlagworte: | AG-014447, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one |
| Anwendung: | Potent, cell-permeable PARP-1 inhibitor |
| CAS | 283173-50-2 |
| MW: | 323.4 D |
ab 43,00 €
