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GSK215
Artikelnummer: TGM-T67843-100mg
Description: GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation. Target: FAK, PROTACs. Smiles:...
| Anwendung: | FAK (PTK2) degradation driving PROTAC |
| CAS | 2743427-26-9 |
| MW: | 985.13 D |
ab 124,00 €
GSK215
Artikelnummer: Cay40835-10
GSK215 is a proteolysis-targeting chimera (PROTAC) composed of the focal adhesion kinase (FAK) inhibitor PND1186 (Cay-17668) linked to the von-Hippel Lindau (VHL) E3 ligase ligand VHL-021. It binds to the FAK kinase domain (IC50 = 15.8 nM) and induces FAK degradation in A549 lung cancer cells with a 50% degradation...
| Schlagworte: | (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino... |
| Anwendung: | FAK (PTK2) degradation driving PROTAC |
| CAS | 2743427-26-9 |
| MW: | 985.1 D |
ab 154,00 €
