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SB 415286
Artikelnummer: TGM-T6659-100mg
Description: SB 415286 is a potent GSK3alpha inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3beta. Target: GSK-3, Apoptosis. Smiles: Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl. References: Coghlan MP, et al. Chem Biol, 2000, 7(10), 793-803.
| Schlagworte: | SB415286 |
| Anwendung: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 264218-23-7 |
| MW: | 359.72 D |
ab 40,00 €
SB-415286
Artikelnummer: Cay10010247-1
Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis, and...
| Schlagworte: | 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Anwendung: | GSK inhibitor |
| CAS | 264218-23-7 |
| MW: | 359.7 D |
ab 43,00 €
SB415286
Artikelnummer: AG-CR1-3658-M001
Yellow solid. Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or methanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.9µM), Stimulates glycogen synthesis in liver cells and induces...
| Schlagworte: | 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione |
| Anwendung: | Potent selective cell permeable ATP-competitive inhibitor of GSK3 inhibitor |
| CAS | 264218-23-7 |
| MW: | 359,7 D |
ab 33,00 €
