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MRTX1719
Artikelnummer: LKT-M704793.1
MRTX1719 is an inhibitor of the PRMT5/MTA complex and may be effective against MTAP-deleted cancers. SMILES: CN1C(=C(C=N1)C2=CC3=C(C=C2)C(=O)NN=C3CN)C4=C(C(=CC(=C4F)Cl)OC5CC5)C#N
| Schlagworte: | MRTX-1719,... |
| Anwendung: | PRMT5/MTA complex inhibitor |
| CAS | 2630904-45-7 |
ab 298,00 €
MRTX-1719
Artikelnummer: Cay36563-1
MRTX-1719 is an inhibitor of the protein arginine methyltransferase 5 (PRMT5) and methylthioadenosine (MTA) complex. It selectively binds to the PRMT5/MTA complex over the PRMT5 and S-adenosyl-L-methionine (SAM) complex (Kds = 0.14 and 9.4 pM, respectively). MRTX-1719 selectively decreases protein dimethylarginine...
| Schlagworte: | (M)-27,... |
| Anwendung: | PRMT5/MTA complex inhibitor |
| CAS | 2630904-45-7 |
| MW: | 464.9 D |
ab 237,00 €
MRTX-1719
Artikelnummer: TGM-T40254-100mg
Description: MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells. Target: Histone Methyltransferase. Smiles: CN1C(=C(C=N1)C=2C=C3C(=CC2)C(=O)NN=C3CN)C4=C(C#N)C(OC5CC5)=CC(Cl)=C4F. References: Targeting the genetic and...
| CAS | 2630904-45-7 |
| MW: | 464.88 D |
ab 397,00 €
