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JNJ-1013
Artikelnummer: Cay41740-1
JNJ-1013 is a proteolysis-targeting chimera (PROTAC) containing the IL-1 receptor-associated kinase 1 (IRAK1) and IRAK4 inhibitor JH-I-25 and a methylated derivative of the PROTAC building block VH 032 (Cay-39982). It degrades IRAK1 with a half-maximal degradation concentration (DC50) value of 3.3 nM in HBL-1...
| Schlagworte: | N-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimet... |
| Anwendung: | IRAK1 degradation driving PROTAC |
| CAS | 2597343-08-1 |
| MW: | 878.1 D |
ab 78,00 €
JNJ-1013
Artikelnummer: TGM-T78054-5mg
Description: JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBalpha, and pSTAT3(Tyr705) [1]. Target: Apoptosis. Smiles:...
| CAS | 2597343-08-1 |
| MW: | 878.05 D |
671,00 €
