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MCC950 sodium
Artikelnummer: TGM-T6887-100mg
Description: MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs, IC50=8.1 nM in HMDMs). MCC950 sodium has no effect on other inflammatory vesicles such as AIM2, NLRC4 or NLRP1. Target: NOD, NOD-like Receptor (NLR). Smiles:...
| Schlagworte: | MCC950, CP-456773 sodium, CP-456773, CRID3 sodium salt |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426.46 D |
ab 31,00 €
MCC950 . Na
Artikelnummer: AG-CR1-3615-M001
Crystalline solid. Soluble in water (10mg/ml), DMSO (10mg/ml), dimethyl formamide or ethanol (1mg/ml). Chemical. CAS: 256373-96-3. Formula: C20H23N2NaO5S. MW: 426.5. Synthetic. Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and...
| Schlagworte: | MCC950, CP-456,773, CRID3, 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea |
| Anwendung: | NLRP3 inflammasome inhibitor |
| CAS | 256373-96-3 |
| MW: | 426,5 D |
ab 39,00 €
MCC950 (sodium salt)
Artikelnummer: Cay34762-25
MCC950 is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation. It inhibits ATP-induced IL-1beta release in LPS-primed mouse bone marrow-derived macrophages (BMDMs, IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1beta release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM, indicating...
| Schlagworte: | CP 456,773, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide,... |
| Anwendung: | NLRP3 inflammasome activation inhibitor |
| CAS | 256373-96-3 |
| MW: | 426.5 D |
ab 39,00 €
