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LC-2
Artikelnummer: TGM-T36256-1mg
Description: LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 µM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C....
| Schlagworte: | PROTAC KRASG12C Degrader-LC-2, LC 2, LC2 |
| Anwendung: | Protac(R) reagent |
| CAS | 2502156-03-6 |
| MW: | 1132.78 D |
ab 261,00 €
LC-2
Artikelnummer: BPS-82058
LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterozygous KRAS G12C cell lines.
| Anwendung: | Protac(R) reagent |
| CAS | 2502156-03-6 |
| MW: | 1132,8 D |
1.123,00 €
