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NEU
PF-07220060
PF-07220060

Artikelnummer: Cay41858-10

PF-07220060 is an inhibitor of cyclin-dependent kinase 4 (Cdk4, Ki = 0.6 nM for Cdk4/cyclin D1). It is selective for Cdk4 over Cdk6 (Ki = 13.9 nM for Cdk6/cyclin D3). PF-07220060 in combination with fulvestrant (Cay-10011269) increases senescence in HR+HER2- breast cancer cells in vitro but does not induce cell...
Schlagworte: Atirmociclib,...
Anwendung: Cdk4 inhibitor
CAS 2380321-51-5
MW: 463.9 D
ab 239,00 €
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CDK4/6-IN-6
CDK4/6-IN-6

Artikelnummer: TGM-T39957-100mg

Description: CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. Target: CDK. Smiles: CC(C)n1c(nc2c(F)cc(cc12)-c1nc(N[C@@H]2CCOC[C@H]2O)ncc1Cl)C(C)(C)O. References: Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as...
Anwendung: Antineoplastic, Cyclin-dependent kinase (CDK) inhibitor
CAS 2380321-51-5
MW: 463.93 D
ab 112,00 €
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