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BI-749327
Artikelnummer: TGM-T10537-100mg
Description: BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6). Target: TRP/TRPV Channel. Smiles: Nc1ccc(nn1)C1CCN(CC1)C(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cc1. References: Lin B L, et al. In vivo selective inhibition of TRPC6...
| CAS | 2361241-23-6 |
| MW: | 442.43 D |
ab 135,00 €
BI-749327
Artikelnummer: Cay39672-1
BI-749327 is an inhibitor of transient receptor potential canonical 6 (TRPC6, IC50 = 13 nM for the mouse channel). It is selective for TRPC6 over TRPC3 and TRPC7 (IC50s = 1,100 and 550 nM, respectively, for the mouse channels). BI-749327 (100, 250, and 500 nM) inhibits TRPC6-mediated reporter gene expression in...
| Schlagworte: | [4-(6-amino-3-pyridazinyl)-1-piperidinyl][4-[4-(trifluoromethyl)phenoxy]phenyl]-methanone |
| Anwendung: | TRPC6 inhibitor |
| CAS | 2361241-23-6 |
| MW: | 442.4 D |
ab 103,00 €
