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Adagrasib
Artikelnummer: TGM-T8369-100mg
Description: Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors. Target: Ras. Smiles:...
| Schlagworte: | MRTX849 |
| Anwendung: | Targets GTPase KRas (KRAS, KRAS2) |
| CAS | 2326521-71-3 |
| MW: | 604.12 D |
ab 60,00 €
MRTX-849
Artikelnummer: Cay31440-5
MRTX-849 is a covalent inhibitor of K-RasG12C, a mutant form of K-Ras that accumulates in cancer cells. It binds to and stabilizes GDP-bound inactive K-RasG12C in an electrophoretic mobility shift assay when used at concentrations ranging from 2 to 15.6 nM. MRTX-849 (33-1,000 nM) reduces phosphorylation of the K-Ras...
| Schlagworte: | (2S)-4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-y... |
| Anwendung: | Covalent K-RasG12C inhibitor |
| CAS | 2326521-71-3 |
| MW: | 604.1 D |
ab 61,00 €
