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HM43239
Artikelnummer: TGM-T9428-100mg
Description: HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates...
| Schlagworte: | Tuspetinib |
| Anwendung: | Targets fms-related tyrosine kinase 3 [EC:2.7.10.1] (FLT3, FLK2, CD135) |
| CAS | 2294874-49-8 |
| MW: | 501.07 D |
ab 63,00 €
HM43239
Artikelnummer: Cay37737-10
HM43239 is an inhibitor of wild-type (WT) and internal tandem duplication (ITD) mutant FMS-related tyrosine kinase 3 (FLT3, IC50s = 1.1 and 1.8 nM, respectively). It also inhibits VEGFR2 and spleen tyrosine kinase (Syk) by 100 and 95%, respectively, when used at a concentration of 100 nM. HM43239 inhibits the growth...
| Schlagworte: | Tuspetinib,... |
| Anwendung: | FLT3 inhibitor |
| CAS | 2294874-49-8 |
| MW: | 501.1 D |
ab 169,00 €
